Ingredient Research by Ingredient

Collagen Matrix (Hydrolyzed Type II + Type I & III) — 15,000 mg

Collagen research is often split by type and form. For example, hydrolyzed collagen (Type I/III)
focuses on peptides and amino acids, while undenatured Type II (UC-II) is studied for immune-mediated joint pathways.
Therefore, we reference both types here.

• 
  Undenatured type-II collagen (UC-II) vs glucosamine/chondroitin in arthritic horses
  
  — DOI:
  
  10.1111/j.1365-2885.2009.01079.x
  
• 
  Bioactive collagen peptides reduce lameness in horses with mild–moderate osteoarthritis (placebo-controlled)
  
  — DOI:
  
  10.1111/jpn.12863
  
• 
  Gelatin supplementation and amino acid response in horses (availability / absorption context)
  
  — DOI: 10.1111/j.2042-3306.2006.tb05612.x

Essential Amino Acids (Lysine, Methionine, Threonine) — Protein Building Support

Amino acids are not “hype ingredients.” Instead, they’re building blocks for tissue turnover and repair.
In addition, equine research commonly evaluates amino acids through growth, nitrogen balance, or protein metabolism outcomes.

L-Lysine — 6,000 mg

• 
  Graded lysine intake and whole-body protein synthesis in yearling horses
  
• 
  Amino acid supplementation (lysine + threonine) and muscle mass outcomes in horses
  
  — DOI:
  
  10.2527/2005.83122783x
  

DL-Methionine — 4,000 mg

• 
  Dietary methionine and growth/nitrogen balance in weanling horses
  
  — DOI:
  
  10.2527/jas.2010-3380
  

L-Threonine — 4,000 mg

• 
  Indicator amino acid oxidation approach for threonine requirements in horses
  
  — DOI:
  
  10.1111/jpn.12927
  

Glycine — 7,000 mg

Glycine is a major structural amino acid in collagen. As a result, it shows up repeatedly in connective tissue research.
Meanwhile, in vitro models can help explain why glycine availability matters for collagen production.

• 
  Glycine concentration and collagen synthesis in chondrocyte culture (mechanism context)
  
  — DOI:
  
  10.1007/s00726-018-2611-x
  

Rosehips (Rosa canina) — 3,500 mg

Rosehip research is commonly discussed in osteoarthritis literature. However, not all preparations are equivalent,
so we reference standardized products when possible.

• 
  Standardized rosehip powder in osteoarthritis: randomized, double-blind, placebo-controlled trial (full text)
  
• 
  Rosehip in osteoarthritis: review/meta-analysis (PDF)
  

Boswellia serrata — 5,000 mg

Boswellia is frequently studied for inflammatory pathway modulation. For that reason, we include both clinical and review literature.

• 
  Systematic review/meta-analysis: Boswellia extract for osteoarthritis outcomes
  
• 
  Sport horse supplementation study including Boswellia (multi-ingredient formula context)
  

Ginger Extract — 400 mg

Ginger is evaluated across inflammation and oxidative stress pathways. Additionally, some equine exercise studies include ginger-containing interventions.

• 
  Ginger + cranberry extracts and exercise/inflammation markers in horses
  
• 
  Meta-analysis: oral ginger in osteoarthritis patients (full text)
  

Gut + Digestive Support (Yeast Culture, Beta Glucan) — 5,000 mg / 225 mg

Digestive stability matters. Therefore, CORE includes yeast culture for hindgut support and beta glucan for immune modulation pathways.
Even so, outcomes vary based on diet type and study design.

Saccharomyces cerevisiae Yeast Culture — 5,000 mg

• 
  Review: Saccharomyces cerevisiae and gut function in horses
  
• 
  Live yeast improves apparent nutrient digestibility in horses on high-fiber diets
  

Beta Glucan (β-1,3/1,6) — 225 mg

• 
  β-Glucan supplementation and LPS-induced endotoxemia model in horses
  
  — DOI:
  
  10.3390/ani14030474
  

Additional Formula References

The remaining ingredients (chia, yucca, cinnamon, magnesium glycinate, coconut water powder, and NAG) each have supporting literature.
Next, we’ll continue expanding the list with additional equine-specific trials and higher-quality systematic reviews.
In the meantime, this page provides a transparent starting point you can verify by clicking through the sources.

CORE Ingredient Research Disclaimer

This page is for educational purposes only. It is not veterinary advice, and it does not claim to diagnose, treat, cure, or prevent disease.
Always consult your veterinarian for medical concerns.