The Synergy Stack: NutriSana EQ CORE + PhytoSana CBD Crumbles

This equine recovery stack pairs NutriSana EQ CORE with PhytoSana CBD Crumbles to support inflammation control, joint comfort, and faster bounce-back in working horses. If your horse has a job and we mean a real job, not just looking pretty in the pasture then this is for you. You’re building an equine recovery stack for a horse that is tight, sore, or slow to come back after work, this is the cleanest place to start.

We built CORE around a simple principle: performance horses break down from accumulation, not from one bad day. The thousand small misses add up. Hidden inflammation that never fully resolves. Connective tissue that gets asked to do more than it’s been supported to handle. Tight muscles that never quite let go. That’s the quiet erosion that shortens careers and sidelines horses before their time.

The Synergy Stack pairs NutriSana EQ CORE with PhytoSana CBD Crumbles because these two products don’t just coexist — they amplify each other. Let’s walk through why.

The Three Power Players Inside CORE

Bovine Collagen: Give the Body What It’s Actually Made Of

Collagen has been a buzzword in the human beauty world for years. But in the equine world, the conversation is different and frankly more important. We’re not talking about skin elasticity. We’re talking about the structural integrity of joints, tendons, and ligaments — the very things that keep your horse sound and working.

Your horse’s connective tissues are made largely of collagen. When those tissues are under stress from training, hauling, and competition, they need the raw materials to repair. Bovine collagen provides exactly those building blocks.

This isn’t wishful thinking. In 2018, a two-centre study on horses with osteoarthritis found that daily supplementation with specific bioactive collagen peptides led to improved soundness and mobility over a 12-week period. 1 The results were described as “promising effects on symptoms of osteoarthritis already after 3 months.” Twelve weeks. That’s one season of consistent support making a measurable difference.

Boswellia Serrata: The Oldest Anti-Inflammatory in the Room

We know what you’re thinking — “Boswellia sounds trendy.” It’s not. This is Frankincense. It’s been used for centuries across Central Africa and the Middle East as a remedy for inflammatory conditions. Modern science has simply caught up to what traditional medicine already knew.

In 2023, a placebo-controlled study on show jumping horses found that supplementation with Boswellia serrata produced a significant downregulation of pro-inflammatory cytokines — specifically interleukin-1α and interleukin-6. 2 Those are the chemical messengers that signal inflammation throughout the body. When they’re running hot after a hard training session or a long haul, recovery slows down and discomfort builds up. Boswellia helps quiet that signal.

The mechanism is well-established: Boswellia works by inhibiting key inflammatory pathways, including 5-lipoxygenase, which is responsible for producing leukotrienes — one of the primary drivers of chronic inflammation. This isn’t a vague herbal claim. It’s a specific, documented pathway with peer-reviewed evidence behind it.

Magnesium Glycinate: The One Your Horse Is Probably Missing

Over 300 enzymatic functions in the equine body depend on magnesium. Three hundred. And yet it’s consistently one of the most under-supplemented minerals in performance horse programs.

Here’s the part that matters most: magnesium and calcium have a push-pull relationship. Calcium is what drives muscle contraction. Magnesium is what allows muscle relaxation. When magnesium is insufficient, calcium wins every time — and you end up with a horse that’s chronically tight, reactive, or in worst-case scenarios, prone to tying up.

We use Magnesium Glycinate specifically because the chelated form has significantly improved bioavailability compared to oxide or sulfate forms. The glycinate bond also matters: glycine is an inhibitory neurotransmitter with documented calming effects, making this form uniquely effective for both physical and neurological tension. Research published in 2017 confirmed that magnesium effectively reduces the onset of stress responses, and the glycinate form’s amino acid pairing makes it the most targeted delivery available. 3

If your horse is tight, reactive, or struggling to recover between sessions, magnesium is one of the first places we’d look.

PhytoSana CBD Crumbles: The Full Spectrum Difference

PhytoSana is our sister company, and the Crumbles are not an afterthought in this stack — they’re a cornerstone.

The key word here is full spectrum. PhytoSana uses full-spectrum hemp, which means the extract contains the full range of cannabinoids naturally present in the plant — including CBG, CBC, and others — along with terpenes. This is called the entourage effect: the idea that all of these compounds working together produce a more powerful result than any single isolated compound could on its own.

The research on CBD in horses is growing fast. A 2024 study published in Frontiers in Veterinary Science found that horses with osteoarthritis showed significant improvements in quality of life and a meaningful reduction in pain markers following CBD administration. 4 The scores in the CBD group were notably lower than the control group across pain and comfort assessments — not a marginal difference, a clinically meaningful one.

A separate 2024 study looking specifically at the combination of CBG and CBD in horses with chronic osteoarthritis found that oral administration promoted pain reduction in adult horses. 5 That’s the CBG in PhytoSana Crumbles doing exactly what it’s designed to do.

Where the Stack Gets Interesting

Running CORE and Crumbles together isn’t just additive — it’s synergistic. Here’s how the key combinations work:

Boswellia + CBD for Inflammation. These two ingredients work on different inflammatory pathways. Boswellia targets the 5-LOX pathway and cytokine signaling. CBD interacts with the endocannabinoid system to modulate inflammatory responses. Running them together means you’re addressing inflammation from multiple angles simultaneously, rather than relying on a single mechanism.

Collagen + CBD for Joint Repair. Collagen provides the structural building blocks for tissue repair. CBD supports the reduction of pain and inflammation that can interfere with that repair process. One builds; the other creates the conditions for building to happen. Together, they represent a complete recovery support approach for the joint.

The Honest Summary

The Synergy Stack is not a shortcut. It’s not a replacement for good forage, a solid mineral program, or smart training decisions. What it is, is a well-reasoned, research-supported layer of support that sits cleanly on top of your existing program and addresses the specific demands you’re placing on your horse’s body.

Stronger connective tissue. Quieter inflammation. Muscles that actually relax. A nervous system that isn’t running on empty. That’s what consistent, intentional supplementation looks like — and that’s what this stack is built to support.

References

Footnotes

1.Dobenecker, B., Reese, S., Jahn, W., Schunck, M., & Oesser, S. (2018). Specific bioactive collagen peptides (PETAGILE®) as supplement for horses with osteoarthritis: A two-centred study. Journal of Animal Physiology and Animal Nutrition, 102(S1), 16–23. PubMed ↩

2.Beghelli, D., Zallocco, L., Angeloni, C., Bistoni, O., Ronci, M., Cavallucci, C., Mazzoni, M.R., Nuccitelli, A., Catalano, C., Hrelia, S., Lucacchini, A., & Giusti, L. (2023). Dietary Supplementation with Boswellia serrata, Verbascum thapsus, and Curcuma longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression. Life, 13(3), 750. PMC ↩

3.Magnesium’s role in stress reduction and the superior bioavailability of chelated forms such as magnesium glycinate is supported by the broader body of equine and veterinary nutrition research. The calming neurotransmitter effects of glycine are well-documented in the scientific literature. See also: Kentucky Equine Research (2020). Calming Nervous Horses: Magnesium May Help. KER Equinews ↩

4.Interlandi, C., Tabbì, M., Di Pietro, S., D’Angelo, F., Gugliandolo, E., & Cuzzocrea, S. (2024). Improved quality of life and pain relief in mature horses with osteoarthritis after oral transmucosal cannabidiol oil administration as part of an analgesic regimen. Frontiers in Veterinary Science, 11, 1341396. Frontiers ↩

5.Aragona, F., Tabbì, M., Gugliandolo, E., et al. (2024). Role of cannabidiolic acid or the combination of cannabigerol/cannabidiol in pain modulation and welfare improvement in horses with chronic osteoarthritis. Frontiers in Veterinary Science, 11, 1496473. Frontiers ↩